Death rates are highest in men and adults aged 50 to 64, though they are increasing more quickly among women and younger adults. The study researchers, led by Ilhem Messaoudi of the School of Medicine at the University of California, Riverside, say their research may help lead to a better understanding of how the immune system works, and how to improve its ability to respond to vaccines and infections. And now, researchers say the odd glass of wine with dinner may actually benefit our health – as new research suggests it can boost the immune system and improve its response to vaccination. The occasional quarantine cocktail isn’t going to inhibit the immune system or set you on a path to alcohol misuse.

Several lines of evidence suggest that alcohol consumption exerts a dose-dependent impact on the host response to infection. Chronic alcohol abuse leads to increased susceptibility to bacterial and viral infections, most notably a 3 to 7-fold increase in susceptibility (Schmidt and De Lint 1972) and severity (Saitz, Ghali et al. 1997) of bacterial pneumonia compared with control subjects. Similarly, the incidence of Mycobacterium tuberculosis infection among alcoholics is increased (Sabot and Vendrame 1969, Hudolin 1975, Kline, Hedemark et al. 1995, Panic and Panic 2001). Alcohol use has also been shown to drive disease progression in chronic viral infections such as human immunodeficiency virus (HIV) (Baum, Rafie et al. 2010) and Hepatitis C (Bhattacharya and Shuhart 2003). In addition, the magnitude of antibody response following vaccination with Hepatitis B is lower in alcoholics compared to controls (Nalpas, Thepot et al. 1993). To elicit a response from the cell-mediated arm of the adaptive immunity, antigens need to be presented to the CD4+ and CD8+ T-cells.

Prenatal Alcohol Exposure and the Developing Immune System

The gut-derived bacterial components together with LPS activate the immune cells localized in the systemic circulation or in target organs such as liver and brain. This causes the increase in pro-inflammatory components that can lead to alcohol liver disease or increased states of neuroinflammation. Additionally, disregarding the specificity of the innate immunity, the influence of alcohol-induced oxidative stress on cardiovascular system has to be considered as well.

Acetate is then released into the blood where it is oxidized to carbon dioxide in the heart, skeletal muscle, and brain (Zakhari 2006). Palindromic SNPs introduce ambiguity for the identity of effect alleles in exposure and outcome data. Sensitivity analysis removing palindromic SNPs (Table 1) revealed similar null associations for all autoimmune disorders. Mendelian randomization methods evaluate does alcohol weaken your immune system an overall casual estimation; it is likely that several distinct causal mechanisms underlie the alcohol–disease relationship, in which a risk factor influences outcome with different magnitudes of causal effect. We examined such a scenario through MR-Clust (Foley et al., 2019), an approach that divides IVs into distinct clusters such that all variants in the cluster have similar causal estimates.

Pro- and anti-inflammatory dose-dependent alcohol effects on the immune system in rheumatoid arthritis

Since genotypes are randomly assigned at conception and always precede disease onset, MR mirrors the randomization process in controlled trials and is less susceptible to confounding and reverse causality (Smith and Ebrahim, 2003). For example, a 2015 study in the journal Alcohol found that binge drinking can reduce infection-fighting white blood cells known as monocytes in the hours after peak intoxication, essentially weakening your immune system. “By damaging those cells in your intestines, it can make it easier for pathogens to cross into your bloodstream,” says Nate Favini, MD, medical lead at Forward, a preventive primary care practice. That is, by drinking too much, you decrease your body’s defensive mechanisms to fight off a cold, virus, or other bacterial or viral infections.

2The different immunoglobulin classes are involved in different aspects of the immune response. However, all immunoglobulins produced by one B-cell and its daughter cells specifically recognize the same antigen. Alcohol use, even single episodes, increases the risk of pneumonia by suppressing the immune system and allowing infection opportunities to take hold. Alcohol can also make pneumonia last longer by allowing the bacteria more time to multiply and inhibiting the body’s ability to fight back. While people who drink alcohol should always be aware of alcohol’s effects on their immune systems, the recent pandemic has made this awareness even more important. Alcohol does suppress people’s immune systems; it does not have to be used for long periods of time to make you more susceptible to infections.

A glass of wine with dinner ‘could improve health’

Similarly, plasma adiponectin concentration was increased after 28 days of daily consumption of 450mL of red wine compared with dealcoholized red wine amongst 34 men, in the absence of changes in subcutaneous and abdominal fat contents as well as body weight (Beulens, van Beers et al. 2006). Finally, primary alveolar macrophages isolated from female mice cultured in 25–100mM ethanol for 24 hours prior to addition of apoptotic cells showed a dose-dependent decrease in efferocytosis, the process of clearing dying cells that is critical to resolution of the inflammatory process after infection. This defect was rescued when cultures were treated with the Rho kinase inhibitor, Y27632 indicative that ethanol reduced efferocytosis through the induction of Rho kinase activity in a dose-dependent manner (Boe, Richens et al. 2010).

drinking alcohol daily lowers immune system